MSF urges immediate response to Nigeria’s worsening diphtheria outbreak

MSF urges immediate response to Nigeria’s worsening diphtheria outbreak

“We’re currently seeing more than 700 people with suspected diphtheria and admitting more than 280 patients on a weekly basis in Kano state’s two diphtheria treatment centres,” says Dr Hashim Juma Omar, MSF emergency project medical doctor. “Women and children under five are the most vulnerable groups and are the people most affected right now in Kano state. And they really need help.”

Diphtheria is a highly contagious and potentially life-threatening bacterial disease which can present in respiratory or cutaneous forms. Without treatment, it can kill half of people infected; even with treatment, the disease is still fatal in five percent of patients. Nigeria’s Centre for Disease Control declared an outbreak of the disease on 20 January 2023; between May 2022 and early September 2023, over 6,000 confirmed cases were recorded. Around 4,000 suspected cases were recorded in the country in August 2023 alone, with over three-quarters coming from Kano state.

MSF teams are responding to the outbreak in Kano, Borno and Bauchi states. However, responding to the outbreak has proved challenging, due to a worldwide shortage of lifesaving diphtheria antitoxin used in treatment, caused by dwindling production capacity.

“While we provided 2,000 doses of diphtheria antitoxin last month in Kano, securing doses of the antitoxin has been one of the biggest challenges in this crisis,” says Dr Omar. “We have placed an urgent additional order of 5,000 doses to cover the needs in our projects, but still, it is not enough.”

In light of these challenges, improved efforts to reduce the disease’s transmission and to strengthen outbreak preparation and response in Nigeria are crucial. This includes vaccination; underlying the outbreak is a low vaccination rate, with only 70 percent of children having received their first dose of diphtheria-tetanus-pertussis vaccine. The decline in immunization led to a reported 25 million un- or under-vaccinated children in Nigeria in 2021. However, funding for vaccines and implementation costs remain a barrier to scaling up; Kano State alone requires millions of doses to target at-risk groups.

In addition to urgent antitoxin and vaccination needs, we urge international organizations to immediately scale up improved surveillance and contact tracing, and measures to strengthen the local health system.

In Maiduguri, Borno state, we have added a 20-bed diphtheria treatment clinic to our Pediatric (corrected spelling) hospital in Gwange III PHC, where over 110 people have been treated by our teams since January. In Kano state, our teams have seen 6,707 people with suspected or confirmed disease cases since January, working in treatment centers with a total bed capacity of 147. In Bauchi state, where we have already treated 21 cases with diphtheria during our usual medical activities in Ganjuwa, we are monitoring the situation there and in Jama'are, and are ready to start diphtheria-specific activities based on the needs.

A health promoter educating a group of male patients and care givers at the Murtala Mohamed specialised hospital on the symptoms of Diphtheria so they can share the knowledge once they go back to their communities. [©Ehab Zawati/MSF]

Our teams are also responding to diphtheria in neighboring countries. In mid-August, we started supporting the Ministry of Health in Guinea, where we work in an epidemic disease treatment center in Siguiri prefecture. More than 100 people have been admitted since the start of our activities.

In collaboration with the Nigerien Ministry of Health, our teams conducted the first round of a preventive vaccination campaign in Kantché and Amsoudou health areas in early September, vaccinating nearly 48,500 people. A second round of vaccinations will take place in early October.

The number of suspected cases in other countries in the region adds to the urgency of increasing access to antitoxin drugs and vaccination initiatives.